| Southeastern Games/Schedule |
| Regular Season |
| Nov. 2, 2021 | Day 20 | Bacone - Southeastern (18) | 50-99  |
| Nov. 5, 2021 | Day 23 | Johnson, FL - Southeastern (18) | 62-110 |
| Nov. 6, 2021 | Day 24 | Brewton Parker - Southeastern (18) | 63-92 |
| Nov. 13, 2021 | Day 31 | Ave Maria - Southeastern (18) | 86-101 |
| Nov. 18, 2021 | Day 36 | Southeastern (18) - Co.Georgia | 85-67 |
| Nov. 20, 2021 | Day 38 | Thomas - Southeastern (18) | 65-76 |
| Nov. 27, 2021 | Day 44 | WVU Tech - Southeastern (18) | 76-75  |
| Nov. 28, 2021 | Day 45 | Southeastern (18) - Union, KY | 74-70 |
| Dec. 2, 2021 | Day 49 | Southeastern (18) - Webber | 75-79 |
| Dec. 4, 2021 | Day 51 | Warner - Southeastern (18) | 70-87 |
| Dec. 11, 2021 | Day 58 | St.Francis, IN (16) - Southeastern (18) | 72-74 |
| Dec. 13, 2021 | Day 60 | Brewton Parker - Southeastern (18) | 62-95 |
| Dec. 14, 2021 | Day 61 | Grace - Southeastern (18) | 76-78 |
| Dec. 17, 2021 | Day 64 | ONU - Southeastern (18) | 67-63 |
| Dec. 18, 2021 | Day 65 | Trinity Christian - Southeastern (18) | 85-97 |
| Dec. 22, 2021 | Day 69 | Spring Arbor - Southeastern (18) | 57-78 |
| Jan. 6, 2022 | Day 80 | Southeastern (18) - FMU | 77-74 |
| Jan. 8, 2022 | Day 82 | St.Thomas, FL - Southeastern (18) | 85-91 |
| Jan. 15, 2022 | Day 89 | Keiser - Southeastern (18) | 57-89 |
| Jan. 19, 2022 | Day 93 | Southeastern (18) - Ave Maria | 106-75 |
| Jan. 22, 2022 | Day 96 | Florida Coll. - Southeastern (18) | 73-89 |
| Jan. 27, 2022 | Day 101 | Thomas Univ. - Southeastern (18) | 68-59 |
| Jan. 29, 2022 | Day 103 | Co.Georgia - Southeastern (18) | 74-84 |
| Feb. 3, 2022 | Day 108 | Southeastern (18) - Warner | 56-79 |
| Feb. 5, 2022 | Day 110 | Webber - Southeastern (18) | 59-71 |
| Feb. 10, 2022 | Day 115 | Southeastern (18) - St.Thomas, FL | 72-83 |
| Feb. 12, 2022 | Day 117 | FMU - Southeastern (18) | 71-74 |
| Feb. 17, 2022 | Day 122 | Southeastern (18) - Keiser | 93-88 |
| Feb. 25, 2022 | Day 130 | Ave Maria - Southeastern (18) | 84-64 |
| National Tournament Day 1 |
| Mar. 11, 2022 | Day 136 | Xavier, LA - Southeastern (18) | 57-56 |
