| Michigan St. Games/Schedule |
| Regular Season |
| Nov. 7, 2022 | Day 1 | NAU - Michigan St. (20) | 55-73  |
| Nov. 11, 2022 | Day 5 | Michigan St. (20) - Gonzaga (10) | 63-64  |
| Nov. 15, 2022 | Day 9 | Kentucky - Michigan St. (20) | 77-86 |
| Nov. 18, 2022 | Day 12 | Villanova - Michigan St. (20) | 71-73 |
| Nov. 24, 2022 | Day 18 | Alabama (4) - Michigan St. (20) | 81-70 |
| Nov. 26, 2022 | Day 20 | Oregon - Michigan St. (20) | 70-74 |
| Nov. 27, 2022 | Day 20 | Michigan St. (20) - Portland | 78-77 |
| Nov. 30, 2022 | Day 24 | Michigan St. (20) - Notre Dame | 52-70 |
| Dec. 4, 2022 | Day 28 | Northwestern - Michigan St. (20) | 70-63 |
| Dec. 7, 2022 | Day 31 | Michigan St. (20) - Penn St. | 67-58 |
| Dec. 10, 2022 | Day 34 | Brown - Michigan St. (20) | 50-68 |
| Dec. 21, 2022 | Day 45 | Oakland - Michigan St. (20) | 54-67 |
| Dec. 30, 2022 | Day 52 | Buffalo - Michigan St. (20) | 68-89 |
| Jan. 3, 2023 | Day 56 | Nebraska - Michigan St. (20) | 56-74 |
| Jan. 7, 2023 | Day 60 | Michigan - Michigan St. (20) | 53-59 |
| Jan. 10, 2023 | Day 63 | Michigan St. (20) - Wisconsin | 69-65 |
| Jan. 13, 2023 | Day 66 | Michigan St. (20) - Illinois | 66-75 |
| Jan. 16, 2023 | Day 69 | Purdue (13) - Michigan St. (20) | 64-63 |
| Jan. 19, 2023 | Day 72 | Rutgers - Michigan St. (20) | 57-70 |
| Jan. 22, 2023 | Day 75 | Michigan St. (20) - Indiana (24) | 69-82 |
| Jan. 26, 2023 | Day 79 | Iowa - Michigan St. (20) | 61-63 |
| Jan. 29, 2023 | Day 82 | Michigan St. (20) - Purdue (13) | 61-77 |
| Feb. 4, 2023 | Day 88 | Michigan St. (20) - Rutgers | 55-61 |
| Feb. 7, 2023 | Day 91 | Maryland - Michigan St. (20) | 58-63 |
| Feb. 12, 2023 | Day 96 | Michigan St. (20) - Ohio St. | 62-41 |
| Feb. 18, 2023 | Day 102 | Michigan St. (20) - Michigan | 72-84 |
| Feb. 21, 2023 | Day 105 | Indiana (24) - Michigan St. (20) | 65-80 |
| Feb. 25, 2023 | Day 109 | Michigan St. (20) - Iowa | 106-112 |
| Feb. 28, 2023 | Day 112 | Michigan St. (20) - Nebraska | 80-67 |
| Mar. 4, 2023 | Day 116 | Ohio St. - Michigan St. (20) | 78-84 |
| Conference Quarter-Finals |
| Mar. 10, 2023 | Day 1 | Ohio St. - Michigan St. (20) | 68-58 |
| National Tournament Day 1 |
| Mar. 17, 2023 | Day 1 | USC - Michigan St. (20) | 62-72 |
| National Tournament Day 2 |
| Mar. 19, 2023 | Day 2 | Michigan St. (20) - Marquette (14) | 69-60 |
| National Tournament Day 3 |
| Mar. 23, 2023 | Day 3 | Michigan St. (20) - Kansas St. (9) | 93-98 |
